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日前，來(lái)自歐洲與美國(guó)等多處機(jī)構(gòu)的科學(xué)家在《自然—遺傳學(xué)》上報(bào)告稱，基于一項(xiàng)超大型研究，他們找到了阿爾茨海默氏癥（俗稱老年癡呆癥）的多個(gè)遺傳變異。

    在這項(xiàng)大范圍關(guān)聯(lián)分析中，科學(xué)家對(duì) 17008 名阿爾茨海默氏癥患者進(jìn)行全基因組關(guān)聯(lián)研究，并選取 37154 名健康個(gè)體作為對(duì)照組，之后再對(duì)另外 8572 名患者進(jìn)行了第二階段研究，選取 11312 名健康個(gè)體作為對(duì)照組。
   

    研究結(jié)果顯示，除了之前已發(fā)現(xiàn)的 APOE 基因組的關(guān)聯(lián)外，他們發(fā)現(xiàn)了 19 個(gè)對(duì)晚發(fā)型老年癡呆癥具有重要影響的基因組區(qū)域，其中 11 個(gè)屬于易感性基因座。

    這項(xiàng)發(fā)現(xiàn)印證了之前老年癡呆癥病理學(xué)涉及到的幾個(gè)途徑，包括免疫反應(yīng)、炎癥、細(xì)胞遷移和類脂運(yùn)疏通路。此外，研究人員還提出了一些可能對(duì)患病風(fēng)險(xiǎn)有影響的其他基因和通路。

    原文檢索：

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