妊娠糖尿病或可增加女性后代肥胖風險
關鍵信息
在這項縱向隊列研究中，研究者對421對母女進行評估。研究發(fā)現，與血糖水平位于下五分位數母親生出的女兒相比，妊娠糖尿病母親生出的女兒BMI≥85th、體重身高比或體脂百分比位于上四分位數風險顯著增加（OR,2.80–3.56）。此外，該研究還發(fā)現，患有妊娠糖尿病，且孕前BMI水平較高的母親生出的女兒肥胖癥患病率最高。
該研究提示，為了降低女性后代肥胖癥發(fā)生風險，需要對妊娠糖尿病進行篩查和干預。
TAKE-HOME MESSAGE
The authors of this longitudinal study evaluated 421 mother–daughter pairs. Compared with daughters born to mothers who had blood glucose levels in the lowest quintile, daughters born to mothers who had gestational diabetes mellitus had increased odds of having a BMI ≥85th percentile or of being in the highest quartile for weight–height ratio or percent body fat （OR, 2.80–3.56）。 The highest rates of adiposity in daughters were seen for mothers who had gestational diabetes and high pregravid BMI.
Screening and intervention for gestational diabetes are warranted to decrease the risk for adiposity in female offspring.
Diabetes Care
Maternal Hyperglycemia During Pregnancy Predicts Adiposity of the Offspring
Diabetes Care 2014 Nov 01;37（11）2996-3002, A Kubo, A Ferrara, GC Windham, LC Greenspan, J Deardorff, RA Hiatt, CP Quesenberry, C Laurent, AS Mirabedi, LH Kushi
From MEDLINE?/PubMed?, a database of the U.S. National Library of Medicine.
This abstract is available on the publisher's site.
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Copyright ? 2014 Elsevier Inc. All rights reserved.
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